Coding

Part:BBa_K4164002

Designed by: Bo Cheng   Group: iGEM22_NAU-CHINA   (2022-09-30)
Revision as of 15:13, 3 October 2022 by JieYang (Talk | contribs)


farnesoid X receptor(FXR)

FXR is a protein from humans, it is a member of the nuclear receptor superfamily of ligand-activated transcription factors， and functions as a receptor for bile acids. It is encoded by the NR1H4 gene in humans. FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid （CDCA） and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 1057

The gene sequence of this part was obtained from NCBI and its GenBank Accession nnumber is: NP_001193908.1

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Categories
Parameters
None