Part:BBa_K3244013

NFAT-Response Ellement

NFAT RE for cytokine expression regulation

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal BamHI site found at 6
  
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

MIT_MAHE 2020

Summary

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors whose activation is controlled by Ca and the Ca/calmodulin-dependent serine phosphatase, calcineurin. It is shown to be important in immune response. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems.The molecular functions of this gene include chromatin binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding and transcription factor binding while the molecular functions include negative regulation of synaptic vesicle exocytosis, positive regulation of transcription by RNA polymerase II and response to salt stress.

References

1. Freeman, A., Franciscovich, A., Bowers, M., Sandstrom, D. J., & Sanyal, S. (2011). NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. Molecular and cellular neurosciences, 46(2), 535–547. https://doi.org/10.1007/s10930-019-09833-8

2. Keyser, P., Borge-Renberg, K., & Hultmark, D. (2007). The Drosophila NFAT homolog is involved in salt stress tolerance. Insect biochemistry and molecular biology, 37(4), 356–362. https://doi.org/10.1016/j.ibmb.2006.12.009

3. Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, Briefings in Bioinformatics, Volume 12, Issue 5, September 2011, Pages 449–462, https://doi.org/10.1093/bib/bbr042