DNA
UreR

Part:BBa_K3710002

Designed by: Luke Roche, Sandra Martinez Diaz, Erik Hanko and Katherine Baker   Group: iGEM21_Manchester   (2021-09-29)
Revision as of 20:06, 21 October 2021 by Erikhanko (Talk | contribs)

UreR: urea-responsive transcriptional regulator

This part encodes the urea-responsive transcriptional regulator UreR, optimised for E. coli codon usage. Proteus mirabilis encodes the transcriptional regulator UreR of the urease gene cluster. It belongs to the AraC/XylS family of transcriptional regulators. UreR upregulates the gene clusters’ subunit transcription in the presence of urea and recruits the accessory proteins (UreDABCEFG),forming an active urease [1].

References:

[1] Poore, C. and Mobley, H. (2003) "Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS", Microbiology, 149(12), pp. 3383-3394.

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