Coding
Part:BBa_K4020002
Designed by: Karina Kurbanova Group: iGEM21_Estonia_TUIT (2021-10-18)
Usage and Biology
SIC1∆N is a gene encoding a protein that inhibits cyclin-dependent kinase complexes and G1 to S phase progression in cell cycle (Hegde, 2010), prevents premature S phase entry, and warrants genome integrity (SIC1 | SGD). It is genomic DNA. The deletion of the first 90 nucleotides encoding the N-terminus, or the regulatory domain of the corresponding protein, results in a non-degradable Sic1 variant.
References
- Hegde, A. N. (2010). Ubiquitin-Dependent Protein Degradation. Comprehensive Natural Products II: Chemistry and Biology, 5, 699–752. https://doi.org/10.1016/B978-008045382-8.00697-3
- SIC1 | SGD. (n.d.). Retrieved October 17, 2021, from https://www.yeastgenome.org/locus/S000004069
References
- Hegde, A. N. (2010). Ubiquitin-Dependent Protein Degradation. Comprehensive Natural Products II: Chemistry and Biology, 5, 699–752. https://doi.org/10.1016/B978-008045382-8.00697-3
- SIC1 | SGD. (n.d.). Retrieved October 17, 2021, from https://www.yeastgenome.org/locus/S000004069
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Categories
Parameters
| None |