Coding

Part:BBa_K3999000

Designed by: Ke ZHU   Group: iGEM21_Shanghai_city   (2021-10-11)
Revision as of 09:03, 18 October 2021 by Zhuke18 (Talk | contribs) (→‎Properties: BBa_K3999000 is the coding sequence of tryptophan hydroxylase (TPH), which catalyzes the L-tryptophan to the 5-hydroxy-L-tryptophan)


TPH


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BamHI site found at 1606
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Profile

Name: TPH

Base Pairs:1641bp

Origin: Synthetic

Properties: BBa_K3999000 is the coding sequence of tryptophan hydroxylase (TPH), which catalyzes the L-tryptophan to the 5-hydroxy-L-tryptophan

Figure1. The protein structure of tryptophan 5-monooxygenase monomer, Human..

Usage and Biology

As the rate-limiting enzyme of 5-HT synthesis, TPH plays an important role in invertebrate neuroregulation. In nature, serotonin is widely present in mammalian tissues, especially in the cerebral cortex and nerve synapses, and has a small amount in plants and fungi. In the pharmaceutical field, serotonin, as a drug, can participate in a variety of physiological functions of the organism, including emotion regulation, behaviour management, sleep cycle maintenance, and removal of harmful free radicals.

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