Part:BBa_K3824005

Buforin IIB

An analog of buforin II, known as buforin IIb has been developed, which contains an α-helical sequence at the end of the C-terminus and has a stronger cytolytic activity than buforin II in microorganisms. Buforin IIb exhibits antitumor activities by specifically targeting cancer cells via interaction with cell surface gangliosides.

Buforin IIb is known for its efficient ability to penetrate cancer cells through an electrostatic interaction with gangliosides on the cancer cell surface. Buforin IIb, however, is also cytotoxic to normal cells at high concentrations. Therefore, reducing this cytotoxicity is critical if buforin IIb is to be used for drug delivery.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

Buforin IIB: RAGLQFPVGRLLRRLLRRLLR (21 aa) (charge = +7)