Part:BBa_I712020

Homo sapiens caspase 3

Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

Group: City of London UK 2021

Author: Julian Chen

Summary: Added information collated from existing scientific studies

Part is involved in the activation cascade of caspases contributing to apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 The part is also involved in the cleavage of Huntingtin (HTT gene). ^[1]

Activity Regulation

Part is inhibited via isatin sulfonamides

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

↑ “CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574. ‌

[1] “CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574. ‌

[1]