Coding

Part:BBa_I712020

Designed by: Anja Korenčič   Group: iGEM07_Ljubljana   (2007-10-21)
Revision as of 20:13, 28 July 2021 by JYC (Talk | contribs)


Homo sapiens caspase 3

Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

Group: City of London UK 2021

Author: Julian Chen

Summary: Added information collated from existing scientific studies

Part is involved in the activation cascade of caspases contributing to apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 The part is also involved in the cleavage of Huntingtin (HTT gene).



Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
//cds/enzyme/protease
//chassis/eukaryote/human
Parameters
None