Coding

Part:BBa_K3450020

Designed by: Priya Sharma   Group: iGEM20_IISER_Bhopal   (2020-10-26)
Revision as of 16:37, 26 October 2020 by Priya sharma193 (Talk | contribs)

Exendin-4

Exendin-4, the dipeptidyl peptidase resistant analogue of GLP-1 was discovered in the venom of a poisonous lizard known as Gila monster (Heloderma suspectum). It has a half-life of about 26 minutes in humans after intravenous infusion which is significantly higher than the half-life of active GLP-1 molecule (1–2 minutes) in humans. [1]

Reference [1] Simonsen, L., Holst, J.J. & Deacon, C.F. Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. Diabetologia 49, 706–712 (2006). https://doi.org/10.1007/s00125-005-0128-9

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None