Part:BBa_K2976000

Toll-like receptor 1

Toll-like receptor 1 (TLR1) is a transmembrane glycoprotein that participates in the innate immune response to microbial agents. TLR1 could form active heterodimers with TLR2 when exposed to some pathogen-associated molecular pattern molecules (PAMPs), and the heterodimers recognize plenty of substances in lipoarabinomannan (LAM) biosynthesis with the help of CD14.

Usage

In 2019 CPU_CHINA project, TLR1 is expressed along with TLR2 and CD14 to form the TLR2:TLR1:CD14 cluster on the designer cell membrane. As a Mtb sensor, the complex could recognize the substances of Mtb and then stimulate the downstream signaling pathway. Then, activated NF-κB initiates transcription of the gene circuits to express other proteins in our project.

Biology

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]