Part:BBa_K2520044

Celiac epitope 3

Celiac

Celiac is a long term autoimmune disorder affecting the internal intestine that is caused due to T cells attacking the Gliadin which is absorbed in the inner wall cells of the small intestine. Gliadin is one of a two proteins that forms gluten. This process leads to severe inflammation, and thus interferes with the absorption of food and greatly increases the chances of contracting colorectal cancer. The prevalence of celiac disease is approximately 0.5% -1% in different parts of the world. The only treatment that eliminates all symptoms (but does not cure the disease) is a strict avoidance of foods containing gluten.

Epitopes

a-Glaiadin 33-mer: a-gliadins in hexaploid wheat are between 25 and 150 copies. The a-gliadin 33-mer is one of the digestion-resistant gluten peptides that is highly reactive to isolated celiac T cells and is the main immunodominant toxic peptide in celiac patients.

References

(1) Gujral, Naiyana, Hugh J. Freeman, and Alan BR Thomson. "Celiac disease: prevalence, diagnosis, pathogenesis and treatment." World journal of gastroenterology: WJG 18.42 (2012): 6036.‏

(2) Ozuna, Carmen V., et al. "Diversification of the celiac disease α‐gliadin complex in wheat: a 33‐mer peptide with six overlapping epitopes, evolved following polyploidization." The Plant Journal 82.5 (2015): 794-805.‏

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

MIT MAHE 2020

Summary

Celiac is a long term autoimmune disorder affecting the internal intestine that is caused due to T cells attacking the Gliadin which is absorbed in the inner wall cells of the small intestine. Gliadin is one of a two proteins that forms gluten. This process leads to severe inflammation, and thus interferes with the absorption of food and greatly increases the chances of contracting colorectal cancer.

References

1. Gujral, N., Freeman, H. J., & Thomson, A. B. (2012). Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World journal of gastroenterology, 18(42), 6036–6059. https://doi.org/10.3748/wjg.v18.i42.6036

2. Ozuna, C. V., Iehisa, J. C., Giménez, M. J., Alvarez, J. B., Sousa, C., & Barro, F. (2015). Diversification of the celiac disease α-gliadin complex in wheat: a 33-mer peptide with six overlapping epitopes, evolved following polyploidization. The Plant journal : for cell and molecular biology, 82(5), 794–805. https://doi.org/10.1111/tpj.12851 "