Part:BBa_K3351002
HBD3, an antimicrobial peptide.
The three human β-defensins, HBD1-3, are 33-47-residue, cationic antimicrobial proteins expressed by epithelial cells. All three proteins have broad spectrum antimicrobial activity, with HBD3 consistently being the most potent. Additionally, HBD3 has significant bactericidal activity against Gram-positive Staphylococcus aureus at physiological salt concentrations.Defensins are small, 3–5 kDa cationic proteins constrained by three disulfide bonds. As a class of proteins, they have broad microbicidal activity against Gram-positive and -negative bacteria, yeast, and some enveloped viruses, although specific defensin peptides often have defined spectra of activity. Like many other antimicrobial peptides, the defensin class of peptides is known to disrupt the membranes of microbes . It has recently been reported that in addition to their antimicrobial activity, defensins may act as chemokines, activating the adaptive immune response .HBD3 possesses bactericidal activity against Gram-positive and -negative bacteria, including multi-drug-resistant S. aureus, vancomycin-resistant Enterococcus faecium, and Burkholderia cepacia in addition to the yeast C. albicans .
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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