Coding
h IL-2

Part:BBa_K3234000

Designed by: Yuxin Huang   Group: iGEM19_NJTech_China   (2019-10-16)
Revision as of 15:39, 16 October 2019 by Registry (Talk | contribs)

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Human interleukin 2

nterleukin-2 (IL-2) is a pleiotropic cytokine, and involves in immune regulation by controlling the differentiation and homeostasis of both pro- and anti-inflammatory T cells. As a naturally occurring cytokine made by T-lymphocytes, IL-2 stimulates the growth and activity of other T-lymphocytes and B-lymphocytes as part of the immune system. Many investigators explored IL-2 and/or IL-2-activated effectors for a variety of malignancies with encouraging but inconclusive results3. IL-2 has been approved by the U.S. Food and Drug Administration (FDA) to treat patients with stage IV (metastatic) melanoma since 1998. The sequence is codon optimized for expression in E coli.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 181


[edit]
Categories
//collections/immune_regulation/inflammatory
Parameters
None