Part:BBa_K2959009
Arabidopsis thaliana Profilin 1
AtPFN1 is a protein extracted from the plant Arabidopsis thaliana. It is a profilin which means that is an actin binding protein. AtPFN1 inhibits fungal growth by penetrating the cell wall and membrane, generating reactive oxygen species and mitochondrial superoxide triggering cell apoptosis, resulting in morphological changes in the cells1.
The binding affinity of antifungal proteins to fungal cells is the most important attribute for their fungal action, even if the mechanism is membranolytic or cell damaging. It has also been demonstrated that these proteins can be transferred across the cell membrane into the cytosolic space and accumulate in the cytosol of the cell by altering the membrane integrity. For cytosolic translocation the mechanisms used by the proteins are direct penetration, vacuolar localization and expansion, partial plasma membrane disruption, transition pore formation and endocytosis. AtPFN1 has exhibited a potent antifungal activity against fungal strains of C. gloesporioides, F. osysporum, C. albicans, and C. glabrata1.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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