Coding
OmpX WT

Part:BBa_K3128031

Designed by: Melodie Dupre   Group: iGEM19_Grenoble-Alpes   (2019-09-23)
Revision as of 12:01, 23 September 2019 by Melo (Talk | contribs)


Outer Membrane Protein X (OmpX) WT gene

The integral outer membrane protein X (OmpX) from Escherichia coli belongs to a family of highly conserved bacterial proteins. Its role is to promote bacterial adhesion and entry into mammalian cells. These proteins have a role in the resistance against attack by the human complement system.(1)

Structure

OmpX consists of an eight-stranded antiparallel all-next-neighbor beta barrel. The structure shows two girdles of aromatic amino acid residues and a ribbon of nonpolar residues that attach to the membrane interior. The core of the barrel consists of an extended hydrogen-bonding network of highly conserved residues. OmpX thus resembles an inverse micelle. (1)

Figure 1

References

(1) Vogt, J., Schulz G. The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence. 1999


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None