Part:BBa_K1927001
This part sequence is collected from the strain K71-77 Esterichia Coli and the gene is called blaCMY-6 class C plasmid – mediated AmpC. These AmpC - lactamases mediate resistance to different antibiotics such as cephalothin, cefazolin, cefoxitin, most penicillins and also - lactamase inhibitor - lactam combinations.(1) They have also the ability to become resistance to several broad spectrum cephalosporins upon therapy because of overexpression of the gene and high mutation rate. The gene can both exist chromosomally and on plasmids. Techniques to identify AmpC - lactamases exist but are not yet optimized for the clinical laboratory. Even though the prevalence of these bacteria is lower compared to other ESBL producing bacteria in the world one should not underestimate its mechanism and it may be both harder to detect and broader in spectrum. This type of gene was also the first to be reported to neutralize penicillin, although it had not been named AmpC in 1940. (1)
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