Part:BBa_K1992002
Histamin-Tar receptor
Novel Histamine-Tar chemoreceptor in E.coli
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 7
Illegal NheI site found at 30 - 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 1355
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 184
Introduction
Tar is a chemoreceptor found in the bacterium E-coli which mediates chemotaxis toward Aspartic acid and away from Nickel and Cobalt (1). Using designs from bioinformatic tool, a noval chemoreceptor, which mediates chemotaxis toward Histamine, was formed by induce directed point mutations to the Tar ligand-binding domain (LBD) (link to K777000 part). This noval receptor is a part of the S.Tar platform.
Usage and Biology
Histamine is a derivative of Histidine, which is also an amino acid as the native Tar ligand. The motivation to mediates chemotaxis toward Histamine is duo to it’s presence in food poison, especially in rotten fish. The new chemoreceptor enable chemotactic attractant response to Histamine, althogth Histamin chemoreceptor could be found in human cells, this is the first time this receptor conducted in bacterium cell.
<NAME>
Introduction Methods Results
conclusion 1)
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