Plasmid

Part:BBa_K1391101:Design

Designed by: Shinjini Saha   Group: iGEM14_MIT   (2014-10-17)
Revision as of 02:37, 18 October 2014 by Registry (Talk | contribs)

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pEXPR_Gantenerumab Variable Human Ig-M Light Chain


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 532
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 532
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 532
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 532
    Illegal AgeI site found at 64
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

Gantenerumab has shown therapeutic potential in recent clinical trials. Human Ig-M can be anchored to the membrane to interact with the b-cell receptor (BCR) complex. Human antibody membrane localization tag is natively found in human, membrane-bound antibodies.



Source

Fusion protein of 3 human peptide sequences


References