Coding
Part:BBa_K1061006
Designed by: mengyi sun Group: iGEM13_SYSU-China (2013-09-12)
Revision as of 06:17, 17 September 2013 by Richardsherlock (Talk | contribs) (Created page with "__NOTOC__ <partinfo>BBa_K1061006 short</partinfo> Hbax, a member of Bcl-2 family, is an apoptosis-related protein. It integrates into the mitochondrial outer membrane, releases c...")
Bax mutant form Hbax, a member of Bcl-2 family, is an apoptosis-related protein. It integrates into the mitochondrial outer membrane, releases cytochrome C and leads to apoptosis.Hbax184a is a mutant of hbax that constantly integrates into mitochondrial outer membrane. We have tried to use them as suicide genes, but they can not induce apoptosis in most cancer cell lines, probably because the pathway that they involve has been blocked in most cancer cells. However, we find that the protein can induce “apoptosis” in the most broadly used eukaryotic chassis, yeast. So it will be very potential to use the gene in some circuit that need to kill the yeast in proper condition.
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Categories
Parameters
| n/a | Bax mutant form |