Part:BBa_K847003
''Deinococcus radiodurans'' Superoxide dismutase, SodMn
Deinococcus radiodurans is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, D. radiodurans can withstand up to 12,000 Gy. Current literature supports this finding with D. radiodurans’ unique genetic makeup which allows it to better handle radiation exposure. The two main effects of radiation exposure to bacterial cells are DNA damage and the creation of toxic superoxide species (Daly 2009). Two DNA damage prevention and repair proteins in D. radiodurans have been shown to outperform analogs in less radiation-tolerant bacteria. To take care of the pesky superoxides, superoxide dismutases are expressed in high levels in D. radiodurans (Slade and Miroslav 2011). These enzymes break the reactive species down into harmless oxygen and hydrogen peroxides. This dismutase uses manganese as a cofactor (Gao, Zhang, Song, Chen, and Zhong 2009).
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 139
- 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 139
- 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 139
- 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 139
- 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 139
- 1000COMPATIBLE WITH RFC[1000]
| protein |