Part:BBa_K339006

CpxP Promoter

The CpxP promoter is a periplasmic stress-activated promoter included in the Cpx regulon.

Usage and Biology

CpxP is a member of the Cpx regulon which docks on to CpxA, a transmembrane protein normally. But in the case of envelope stress causing protein misfolding in the periplasmic space, CpxP detaches from CpxA and attaches to the misfolded protein in the periplasmic space.

http://i872.photobucket.com/albums/ab287/iGEMCalgary_2010/Cpxresponse.png

This diagram illustrated that the CpxP promoter is the most sensitive in the stress regulon. CpxP is followed by CpxR and DegP respectively. These were selected because they are some of the most sensitive in the periplasmic stress detection pathways