Coding

Part:BBa_K364303:Experience

Designed by: Katalin Sandor   Group: iGEM10_Debrecen-Hungary   (2010-08-12)
Revision as of 01:45, 26 October 2010 by Lityupix (Talk | contribs) (→‎Ligand)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

This experience page is provided so that any user may enter their experience using this part.
Please enter how you used this part and how it worked out.

Ligand

The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime.

Physiological effects of DAF-12

daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. It has effects also on resistance to oxidative and thermal stress which makes daf-12 the first gene with alleles that can extend or shorten lifespan.

Possible applications od DAF-12 LBD

DAF-12 LBD can be fused with various DBDs to activate the expression of chosen genes by addition of dafachronic acids (ligand).

Applications of BBa_K364303

User Reviews

UNIQ0a39227555117139-partinfo-00000000-QINU UNIQ0a39227555117139-partinfo-00000001-QINU