Part:BBa_K5477017
UGT1A1 - UDP-glucuronosyltransferase 1A1
UGT1A1 (UDP-glucuronosyltransferase 1A1) is an enzyme belonging to the UDP-glucuronosyltransferase (UGT) family and plays a role in the detoxification of environmental pollutants such as dioxins and polychlorinated biphenyls (PCBs) through glucuronidation (2). This is a process where glucuronic acid is added to lipophilic molecules, increasing their solubility (1) (2). This reaction converts these toxic compounds into more hydrophilic metabolites, making them easier to excrete.
Incorporating UGT1A1 into the detoxification system together with UDP- glucose dehydrogenase aims to detoxify these compounds. The following composites and devices, where this part was used, are listed below: BBa_K5477036 and BBa_K5477047.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 706
- 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 1000COMPATIBLE WITH RFC[1000]
References
1. Dhakal K, Gadupudi GS, Lehmler HJ, Ludewig G, Duffel MW, Robertson LW. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res. 2018 Jun 1;25(17):16277–90.
2. Kasai N, Sakaki T, Shinkyo R, Ikushiro S ichi, Iyanagi T, Kamao M, et al. SEQUENTIAL METABOLISM OF 2,3,7-TRICHLORODIBENZO-P-DIOXIN (2,3,7-triCDD) BY CYTOCHROME P450 AND UDP-GLUCURONOSYLTRANSFERASE IN HUMAN LIVER MICROSOMES. Drug Metab Dispos. 2004 Aug 1;32(8):870.
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