Part:BBa_K5115070
YejM
Introduction
YejM is an anti-adaptor protein that can regulate the synthesis of the LPS. In E.coli, LPS levels are under feedback control, achieved by FtsH-mediated degradation of LpxC. FtsH is a membrane- bound AAA+ protease, and its protease activity toward LpxC is regulated by essential membrane proteins LapB and YejM. YejM can compete with FtsH for LapB to inhibit LpxC degradation, thus guaranteed the expression level of LPS.[1] LPS is a basic component of E.coli's outer membrane. Sufficient expressing of LPS can help with the bacteria's survival. So, as a result, the YejM can indirectly improve E.coli's viability.
Usage and Biology
Our MINERAL is designed to be put into half-open water. To ensure that it can function stably, we choose to use YejM to raise E.coli's viability.
Characterization
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 1440
- 1000COMPATIBLE WITH RFC[1000]
References
- ↑ Shu, S., & Mi, W. (2022). Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli. Nature Communications, 13(1), 4576.
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