Part:BBa_K4670134

Encodes a member of the GATA factor family of zinc finger transcription factors.

GATA4 is a member of the GATA family of zinc finger transcription factor, which regulates gene transcription by binding to GATA elements. GATA4 was originally discovered as a regulator of cardiac development and subsequently identified as a major regulator of adult cardiac hypertrophy. GATA4 is expressed in both embryo and adult cardiomyocytes where it functions as a transcriptional regulator for many cardiac genes, and also regulates hypertrophic growth of the heart. GATA4 promotes cardiac morphogenesis, cardiomyocytes survival, and maintains cardiac function in the adult heart. We aim to use GATA 4 transcription factor to synthesize a fusion protein to enter the cell by endocytosis, in order to suppress the activation of Hepatic stellate cell. Thus, the symptoms consequential with primary chronic liver disease is suppressed by deactivating active HSCs.