Part:BBa_K256004
NorR
DNA-binding transcriptional activator, B2709, NorR, YgaA, transcriptional regulator of the anaerobic response to reactive nitrogen species
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 655
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 430
MIT MAHE 2020
Summary Nitric oxide (NO) induces NO-detoxifying enzymes in Escherichia coli suggesting sensitive mechanisms for coordinate control of NO defense genes in response to NO stress. Exposure of E. coli to sub-micromolar NO levels under anaerobic conditions rapidly induces transcription of the NO reductase (NOR) structural genes. This protein is involved in the pathway nitric oxide reduction, which is part of Nitrogen metabolism. It also acts as a transcriptional activator for at least the norVW operon. It binds to the promoter region of norVW, to a consensus target sequence, GT-(N7)-AC, which is highly conserved among proteobacteria.
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