Coding

Part:BBa_K4586011

Designed by: Mohamed Mohamed Saad Aboelghare   Group: iGEM23_AFCM-Egypt   (2023-09-15)
Revision as of 08:52, 21 September 2023 by Mahmoud sayed (Talk | contribs) (→‎Usage)


STEAP3

Part Description

STEAP3 is a metallic reductase enzyme that is also known as TSAP6, which is involved in promoting apoptosis and exosome biogenesis and can reduce iron and copper. It has the ability to convert iron from an insoluble ferric to a soluble ferrous form.

Usage

This part is implemented in our system to improve the efficacy of our therapeutic agent by increasing the default level of exosome synthesis within our engineered MSC. The only mechanism discovered is that TSAP6 modulates its downstream transferrin receptor genes, which is a pathway related to exosomal secretion. However, its specific mechanism for promoting exosome secretion is still unknown. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1103
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI site found at 693


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Categories
Parameters
None