Coding
Part:BBa_K4165015
Designed by: Hossam Hatem Group: iGEM22_CU_Egypt (2022-09-29)
Revision as of 14:47, 10 October 2022 by Esraa Elmligy (Talk | contribs)
UBE2W
Ubiquitin-conjugating E2 ligase that has a role in the ubiquitination cascade for protein degradation.
Usage and Biology
This E2 ubiquitin-conjugating enzyme UBE2W is the key participant in the trio of enzymes as it is responsible for the monoubiquitylation of TRIM21 E3 ligase to initiate its polyubiquitylation by the UBE2N/UBE2V2 heterodimer.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Refrences
1- Komander D. (2009). The emerging complexity of protein ubiquitination. Biochemical Society transactions, 37(Pt 5), 937–953. https://doi.org/10.1042/BST0370937
2- David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003
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Categories
Parameters
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