Protein_Domain

Part:BBa_K4375010

Designed by: Zska Csorba   Group: iGEM22_ELTE   (2022-09-28)
Revision as of 16:21, 10 October 2022 by NYMP (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)


13 aa long GS-linker

A 13 amino acid long GS linker (Glycine-Serine linker), which gives the possibility of a flexible linkage between protein domains.



Usage and Biology

The GS linker is a flexible linker that can connect different protein domains or regions. This stretch is rich in serine and glycine amino acids and thus provides high mobility to the protein regions conjugated to it. GS linkers are usually useful in connecting antibody fragments to achieve better antigen binding or improve protein folding.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Reference

Chen, X.; Zaro, J. L.; Shen, W.-C. Fusion Protein Linkers: Property, Design and Functionality. Advanced Drug Delivery Reviews 2013, 65 (10), 1357–1369. https://doi.org/10.1016/j.addr.2012.09.039.


[edit]
Categories
Parameters
None