Part:BBa_K4165208
Coh2 linked with tau binding peptide (M4W39) and GSGS linker
Fusion protein consists of Tau binding peptide (M4W39) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system with linker GSGS [BBa_K4165065]
Usage and Biology
Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim . we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregations . Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing.
3D Modeling and Ranking
This fused protein was modeled using Alphafold software and after running our quality assessment code it got a score of 4 out of 6 according to the parameters of the QA code: C-beta deviations, clash score, Molprobity, Ramachandran favored, Ramachandran outliers, Q mean 4, and Q mean 6. This protein was excluded due to its low QA score as compared to other models.
Figure 1. Predicted 3D structure of CoH2-(GSGS)-M4W39 protein.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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