Part:BBa_K4165194
Amyloid beta peptide 14 (Aβ 33-42)
This part encodes a part of the Amyloid 𝛽 fragment (33-42) which has the ability to bind to A𝛽 plaques inside the brain.
Usage and Biology
Type of Amyloid-beta binding peptide start from amino acid 33 to 42, this peptide characterized by its solubility which is 134 ± 37 μm.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Features and codon optimize
This sequence is optimized for E. coli bacteria
Source
Homo sapiens Amyloid-beta precursor protein - UniProt (P05067)
Dry lab
Modeling
Due to the nonavailability of a model to this peptide we modeled it in our used modeling software's and after the Running of the quality assessment, the models have been scored to get the top model.
Figure 1.: Amyloid-beta (33-42) visualized by Pymol.
References
1- Zhao, Y., Cai, J., Liu, Z., Li, Y., Zheng, C., Zheng, Y., ... & Liu, Y. (2018). Nanocomposites inhibit the formation, mitigate the neurotoxicity, and facilitate the removal of β-amyloid aggregates in Alzheimer’s disease mice. Nano letters, 19(2), 674-683.
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