Coding

Part:BBa_K4165139

Designed by: Salma Sobhy Sadek   Group: iGEM22_CU_Egypt   (2022-09-30)
Revision as of 16:49, 5 October 2022 by M Zaki (Talk | contribs)


TLKIVW Peptide

Tau binding peptide targeting the PHF seed of Tau

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Dry Lab

Modeling

TLKIVW were modeled by AlphaFold2 and Apptest. The best model obtained from Apptest 


                            Figure 1: Predicted 3D structure of Synthetic peptide TLKIVW.


Table 1: Quality assessment parameters of TLKIVW model.


References

1.Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., ... & Eisenberg, D. (2011). Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475(7354), 96-100.


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