Coding
Part:BBa_K4020009
Designed by: Karina Kurbanova Group: iGEM21_Estonia_TUIT (2021-10-18)
Usage and Biology
Prolyl peptidase is a large enzyme that belongs to a distinct class of serine peptidases. Prolyl peptidase functions in immune and inflammatory responses and nutrient digestion. Prolyl peptidase cleaves C-terminally of proline residues in peptides which are at least 30 amino acids long (Fülöp et al., 1998). Its optimal pH is 4-5 (Shan et al., 2005). In human, prolyl peptidase is believed to be responsible for the maturation and degradation of peptide hormones and neuropeptides (Shan et al., 2005).
References
- Fülöp, V., Böcskei, Z., & Polgár, L. (1998). Prolyl Oligopeptidase: An Unusual β-Propeller Domain Regulates Proteolysis. Cell, 94(2), 161–170. https://doi.org/10.1016/S0092-8674(00)81416-6
- Shan, L., Mathews, I. I., & Khosla, C. (2005). Structural and mechanistic analysis of two prolyl endopeptidases: Role of interdomain dynamics in catalysis and specificity. PNAS March, 8(10), 2021. www.pdb.org
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Categories
Parameters
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