Part:BBa_K3861010

Pep8

Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft.¹ p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers.^2,3 Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin.¹ Pep8 is part of the composite parts BBa_K3861024 and BBa_K3861026.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

References

1. Lucchesi, C. A., Zhang, J., Ma, B., Chen, M. & Chen, X. Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression. Cancer Res. 79, 807–818 (2019).
2. Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000).
3. Vousden, K. H. & Prives, C. Blinded by the Light: The Growing Complexity of p53. Cell 137, 413–431 (2009).