Protein_Domain

Part:BBa_K4040013

Designed by: Tong Yin   Group: iGEM21_NMU_China   (2021-09-14)
Revision as of 13:19, 29 September 2021 by Ytong (Talk | contribs)


mIL-6R

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (GP130BBa_K4040032), a receptor subunit also shared by many other cytokines. The classical signaling pathway is triggered by the hemerer complex formed by mIL-6R. The usage in our project can be found in IL6R-TCS-Gal4-KRAB(BBa_K4040021) and IL6R-TCS-tTA(BBa_K4040022).

References

Narazaki M, Kishimoto T. The Two-Faced Cytokine IL-6 in Host Defense and Diseases. Int J Mol Sci. 2018 Nov 9;19(11):3528. doi: 10.3390/ijms19113528. PMID: 30423923; PMCID: PMC6274717.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 142
    Illegal NgoMIV site found at 166
    Illegal NgoMIV site found at 238
    Illegal NgoMIV site found at 250
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None