Part:BBa_K223053

hIL-6 Generator (Freiburg-compatible)

This gene generates Interleukin 6, an important cell signaling molecule that acts as both a pro- and anti-inflammatory cytokine

Sequence and Features

Assembly Compatibility:

• 10
  INCOMPATIBLE WITH RFC[10]

  Illegal prefix found in sequence at 1
  Illegal suffix found in sequence at 600
  
• 12
  INCOMPATIBLE WITH RFC[12]

  Illegal EcoRI site found at 1
  Illegal NheI site found at 465
  Illegal SpeI site found at 601
  Illegal PstI site found at 615
  Illegal NotI site found at 7
  Illegal NotI site found at 608
  
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal EcoRI site found at 1
  
• 23
  INCOMPATIBLE WITH RFC[23]

  Illegal prefix found in sequence at 1
  Illegal suffix found in sequence at 601
  
• 25
  INCOMPATIBLE WITH RFC[25]

  Illegal prefix found in sequence at 1
  Illegal suffix found in sequence at 591
  
• 1000
  INCOMPATIBLE WITH RFC[1000]

  Illegal BsaI.rc site found at 156
  Illegal SapI site found at 570
  

MIT_MAHE 2020

Summary

This gene generates Interleukin 6, an important cell signaling molecule that acts as both a pro- and anti-inflammatory cytokine. This cytokine has a wide variety of biological functions in immunity, tissue regeneration, and metabolism. IL6 binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells.

References

1. Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019). Targeting Interleukin-6 Signaling in Clinic. Immunity, 50(4), 1007–1023. https://doi.org/10.1016/j.immuni.2019.03.026

2. Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004). IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. The Journal of clinical investigation, 113(9), 1271–1276. https://doi.org/10.1172/JCI20945 "