Coding

Part:BBa_K108021

Designed by: Qi Liu   Group: iGEM08_Tsinghua   (2008-10-23)
Revision as of 11:06, 26 July 2021 by Ng849 (Talk | contribs)

Fis

global DNA-binding transcriptional dual regulator of E.coli

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

  • Group: City of London UK 2021
  • Author: Lucas Ng
  • Summary: Added information collated from existing scientific studies

fis is an activator of ribosomal RNA transcription as well as other genes, as a key part in upstream up-regulation of rRNA promoters [1]

It binds to a recombinatorial enhancer helix-turn-helix sequence motif, facilitating hin-mediated DNA inversion [2] as well as binding to hundreds of transcriptionally active and inactive AT-rich sites [3] approximately half of which are located in non-coding DNA [4]

It prevents the initiation of oriC-mediated DNA replication [5]


[edit]
Categories
//cds/transcriptionalregulator/activator
//cds/transcriptionalregulator/repressor
Parameters
None