Coding

Part:BBa_K2520027

Designed by: Dana Kadosh   Group: iGEM17_TECHNION-ISRAEL   (2017-10-25)
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Pro-insulin

Diabetes type 1

Diabetes type 1 is a chronic disease of the pancreas that is caused due to T cells attacking the insulin producing beta cells, within the pancreas. Globally, nearly 40 million people suffer from type I diabetes. This disease leads pancreatic dysfunction and insulin dependence.

Proinsulin: Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans. Proinsulin formed by three distinct chains: The A chain, B chain, and the area connecting the two chains - C peptide.

Proinsulin.jpeg

References

(1) Wong, F. Susan, et al. "Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library." Nature medicine 5.9 (1999): 1026-1031.‏

(2) Narendran, Parth, Stuart I. Mannering, and Leonard C. Harrison. "Proinsulin—a pathogenic autoantigen in type 1 diabetes." Autoimmunity reviews 2.4 (2003): 204-210.‏ APA Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None