Coding

Part:BBa_K2309026

Designed by: Yijing Gong   Group: iGEM17_XJTLU-CHINA   (2017-09-27)
Revision as of 08:44, 1 November 2017 by Zixin.Rong (Talk | contribs)


Komodo dragon-inspired synthetic peptide DRGN-1 for Lactococcus lactis

The novel synthetic peptide DRGN-1 (inspired by a peptide identified from Komodo dragon) exhibits pathogen-directed and host-directed activities in promoting the clearance and healing of polymicrobial (Pseudomonas aeruginosa & Staphylococcus aureus) biofilm infected wounds. We considered it initially as one of our antimicrobial peptides.

A histone H1-derived peptide from the Komodo dragon (Varanus komodoensis)were defined as VK25. a synthetic peptide called DRGN-1 were designed based on VK-25. DRGN-1 has anti-biofilm activity of both peptides against Pseudomonas aeruginosa and Staphylococcus aureus rather than VK-25.Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (Pseudomonas aeruginosa and Staphylococcus aureus)-infected murine wounds. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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