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Part:BBa_K1590006

Designed by: Manuel Blank   Group: iGEM15_Dundee   (2015-09-10)
Revision as of 18:36, 18 September 2015 by Manoo (Talk | contribs)

Human Lanosterol Synthase

Lanosterol Synthase catalyses the reaction from 2,3-oxido-squalene (squalene epoxide) to Lanosterol. It is one of the enzymes in the enzymatic cascade that converts squalene to cholesterol through stepwise modifications of the substrate.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 819
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 666
    Illegal AgeI site found at 145
    Illegal AgeI site found at 283
  • 1000
    COMPATIBLE WITH RFC[1000]


Usage and Biology

Lanosterol synthase (LSS) an oxidosqualene cyclase (OSC) enzyme that specifically binds to squalene epoxide (2,3- oxidosqualene), which is present in fingerprints. Our modelling showed us that squalene epoxide is the compound with the most distinct degradation pattern in fingerprints, and it was hence selected as an appropriate target for approximating the age of a fingerprint.



Functional Parameters

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Categories
Parameters
None