Coding
Part:BBa_K1590008
Designed by: Manuel Blank Group: iGEM15_Dundee (2015-09-09)
Lactoferrin Binding Protein
Coding sequence for Lactoferrin Binding Protein of Neisseria meningitidis. This protein sequesters iron for the host from Lactoferrin.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 172
- 1000COMPATIBLE WITH RFC[1000]
Usage and Biology
A majorfound in saliva is a free iron sequestering compound known as lactoferrin, a protein involved in the innate immune system. Neisseria meningitidis is a gram-negative bacterium with an iron-binding outer membrane protein called lactoferrin binding protein A (LbpA). N. meningitidis uses this LbpA to extract iron from the host lactoferrin under pathogenic conditions to allow for the bacterium to perform essential cellular metabolism such as energy generation and DNA replication.
Functional Parameters
[edit]
Categories
Parameters
None |