Part:BBa_K1061003
RIP 3
Receptor interacting protein 3, also a serine/threonine kinase that play an important role in cell apoptosis and necrosis. It can induce necrosis via the interaction with RIP 1.[1]
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 623
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 267
- 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 1198
Functional experiment
We test the death-induction effect of RIP 3 in two kinds of cell lines, here's the result.We also characterized it quantitively by using FACS.
kill range
For each suicide gene, it is important to know which cancer cells and normal cells it will kill.So that people can speficially choose gene that will be functional in their project when duelling about cancer. And we define this new feature for each suicide gene that we submitted. The list will be changed due to more and more experiment will be done. We highly recommend people to adopt this feature as an important characteristic of suicide gene.
References:
[1] Duan-Wu Zhang et al. 2009,RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis,Science 325:332-336
n/a | RIP 3 |