Coding

Part:BBa_K892405

Designed by: Rashmi Ravichandran, Andy H.W.Chan   Group: iGEM12_Washington   (2012-09-28)
Revision as of 16:34, 3 October 2012 by Rravic (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

HB80.4 starting varient

The starting HB80.4 flu binder originally shown to bind to various subtypes of Hemagglutinin in group 1. Originally identifited by Fleishman et al., further optimized by Whitehead et al.

Usage and Biology

This binder is known to bind to multiple HA subtypes in group 1. See papers for more details:

[1] Whitehead, Timothy, et al. "Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing." Nature Biotechnology 30.6 (2012):543-548.

[2] Fleishman, Sarel, et al."Computational design of proteins targeting the conserved stem region of influenza hemagglutinin." Science 332.6031 (2011): 816-821.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 166
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None