Difference between revisions of "Part:BBa K316015"

 
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
−
 
 
__NOTOC__
 
__NOTOC__
 
<partinfo>BBa_K316015 short</partinfo>
 
<partinfo>BBa_K316015 short</partinfo>
  
−
ComD is the histidine kinase of a two-component signal transduction signaling pathway in a Streptococcus pneumoniae quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1) which is coded for by the ComC gene. Upon detection of CSP-1, ComD will autophosphoylate and then phosphorylate and activate the response regulator, ComE
+
 
 +
 
 +
ComD is the histidine kinase of a two-component signal transduction signaling pathway in a ''Streptococcus pneumoniae'' quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1)[http://www.ncbi.nlm.nih.gov/pubmed/17328748] which is coded for by the comC gene. ComD is sensitive to ComC concentrations as low as 2-10 ng/ul[http://www.ncbi.nlm.nih.gov/pubmed/7479953]. Upon detection of CSP-1, ComD will autophosphoylate and then phosphorylate and activate the response regulator, ComE <bbpart>BBa_K316016</bbpart>.
 +
 
 +
 
 +
 
 +
For more information on ComCDE system, please check our [http://2010.igem.org/Team:Imperial_College_London/Modules/Signaling wiki]
 +
 
  
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here
Line 9: Line 15:
  
 
<!-- -->
 
<!-- -->
−
<span class='h3bb'>Sequence and Features</span>
+
<span class='h3bb'><big>'''Sequence and Features'''</big></span>
 
<partinfo>BBa_K316015 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K316015 SequenceAndFeatures</partinfo>
  
Line 17: Line 23:
 
<partinfo>BBa_K316015 parameters</partinfo>
 
<partinfo>BBa_K316015 parameters</partinfo>
 
<!-- -->
 
<!-- -->
 +
 +
===References===
 +
<biblio>
 +
#1 Halfmann et.al. FEMS Microbiol Lett. 2007 Mar;268(2):217-24
 +
#2 Håvarstein et.al. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11140-4
 +
</biblio>

Latest revision as of 03:39, 28 October 2010

ComD receptor for CSP-1 (S. pneumoniae), phosphorylates ComE


ComD is the histidine kinase of a two-component signal transduction signaling pathway in a Streptococcus pneumoniae quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1)[http://www.ncbi.nlm.nih.gov/pubmed/17328748] which is coded for by the comC gene. ComD is sensitive to ComC concentrations as low as 2-10 ng/ul[http://www.ncbi.nlm.nih.gov/pubmed/7479953]. Upon detection of CSP-1, ComD will autophosphoylate and then phosphorylate and activate the response regulator, ComE BBa_K316016.


For more information on ComCDE system, please check our [http://2010.igem.org/Team:Imperial_College_London/Modules/Signaling wiki]


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1363
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


References

<biblio>

  1. 1 Halfmann et.al. FEMS Microbiol Lett. 2007 Mar;268(2):217-24
  2. 2 Håvarstein et.al. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11140-4

</biblio>