View source for Part:BBa K4256177


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<partinfo>BBa_K4256177 short</partinfo>

The expression product of the BBa_K4256177 system, FNR, is a sensing protein containing the [Fe-S] cluster that acts as a transcriptional regulator to regulate gene expression downstream of the oxygen-controlled promoter HIP-1.Under hypoxic conditions, the [4Fe-4S] cluster, which is stably present in the FNR protein, can prompt the FNR protein to form a homodimer, and this dimer can specifically bind to DNA sites and initiate ccdA expression downstream of the target promoter HIF-1; under normoxic conditions, the [4Fe-4S] cluster is disassembled, and the FNR dimer is depolymerized, so the initiation of ccdA transcription is repressed.

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===Usage and Biology===

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<span class='h3bb'>Sequence and Features</span>
<partinfo>BBa_K4256177 SequenceAndFeatures</partinfo>


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===Functional Parameters===
<partinfo>BBa_K4256177 parameters</partinfo>
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