Part:BBa_K2520039
MOG 2
Introduction
In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged.
In MS disease, T cells attack 3 types of glycoprotein:
1) Myelin basic protein (MBP)
2) Proteolipid protein (PLP)
3) myelin oligodendrocyte glycoprotein (MOG)
Experimental autoimmune encephalomyelitis (EAE)
EAE is a CD4' T cell-mediated inflammatory disease of the central nervous system (CNS) induced in experimental animals with CNS homogenate, myelin or myelin components. In its chronic form, EAE is a well accepted experimental model for multiple sclerosis (MS).
Epitopes
MOG glycoprotein is the only CNS autoantigen known to induce both a T-cell response and a demyelinating autoantibody response in EAE
Therefore, we chose the three epitopes that induced the most significant immune response. MOG2 is the second epitope that appears in the MOG glycoprotein sequence (35-55)
References
Mendel, Itzhack, Nicole Kerlero de Rosbo, and Avraham Ben‐Nun. "A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells." European journal of immunology 25.7 (1995): 1951-1959. APA
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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