Part:BBa_K1935005
White collar-2 (WC-2) - photoreceptor in Neurospora tetrasperma
May function as a transcription factor involved in light regulation. Binds and affects blue light regulation of the al-3 gene. Wc-1 and wc-2 interact via homologous PAS domains, bind to promoters of light regulated genes such as frq, and activate transcription. May bind directly to frq.
WC-1 and WC-2 are transcription factors encoded by the genes wc-1 and wc-2. Zinc finger DNA-binding domains allow WC-1 and WC-2 to bind to DNA and act as transcription factors. Both WC-1 and WC-2 have PAS domains that allow them to bind to other proteins. WC-1 and WC-2 typically heterodimerize in vivo to form the White Collar Complex (WCC), which acts as a transcription factor complex. In vitro, WC-1 can also homodimerize with itself and heterodimerize with other PAS proteins. WC-1 and WC-2 bind to the promoter elements of the genes that they transcriptionally activate. Function in the circadian clock.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 25
Illegal BamHI site found at 61
Illegal BamHI site found at 835 - 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 1251
Illegal NgoMIV site found at 1310
Illegal AgeI site found at 857 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI site found at 402
Illegal BsaI.rc site found at 770
Illegal SapI.rc site found at 652
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