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Alcohol use disorder (AUD) is a major global health concern (Peacock et al., 2018). There are considerable efforts being made to identify new molecular targets within the brain for the development of more effective therapies to treat this addictive disorder. As an approach in this direction, new research by Mews et al., 2019 published recently in Nature has demonstrated that the tertiary metabolite of alcohol (acetyl-CoA) is important in regulating ethanol’s effects in the brain and serves as a substrate in directly promoting histone acetylation, thereby regulating gene expression in the neurons and alcohol-related behaviors