Part:BBa_K847002
''Deinococcus radiodurans'' DNA repair mechanism, DpsMP1
Deinococcus radiodurans is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, D. radiodurans can withstand up to 12,000 Gy. Current literature supports this finding with D. radiodurans’ unique genetic makeup which allows it to better handle radiation exposure. The two main effects of radiation exposure to bacterial cells are DNA damage and the creation of toxic superoxide species (Daly 2009). Two DNA damage prevention and repair proteins in D. radiodurans have been shown to outperform analogs in less radiation-tolerant bacteria. By binding to DNA, the protein DpsMP1 (DNA-binding proteins from starved cells) protects it from the reactive superoxide species formed by ionizing radiation (Slade and Miroslav 2011).
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 70
Illegal NgoMIV site found at 201 - 1000COMPATIBLE WITH RFC[1000]
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