Part:BBa_K5499006
Trans-activator of transcription (TAT)
Trans-activator of transcription (TAT) peptide is an efficient cell-penetrating peptide, which could penetrate the plasma membrane as well as the nuclear envelop of majority of living cells.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Profile
Name: Trans-activator of Transcription (TAT)
Base Pairs: 33 bp
Origins: TAT is derived from the Human Immunodeficiency Virus (HIV).
Properties: TAT peptide can effectively cross the lipid bilayer of the plasma membrane, enabling intracellular delivery of cargo such as proteins, peptides, and nucleic acids.
TAT utilizes a receptor/transporter-independent pathway for internalization, allowing it to bypass traditional uptake mechanisms, which may be saturated in high concentrations.
Usage and Biology
The TAT protein is widely used in synthetic biology and gene therapy as a transduction agent. Its ability to penetrate cellular membranes allows researchers to deliver various therapeutic molecules, including proteins, peptides, and nucleic acids, directly into target cells. This capability is particularly useful for enhancing the efficiency of gene delivery systems and developing treatments for diseases such as cancer and genetic disorders. Its ability to cross the blood-brain barrier (BBB) makes it invaluable for targeting brain tissues.
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